Searchable abstracts of presentations at key conferences in endocrinology

ea0099ep474 | Pituitary and Neuroendocrinology | ECE2024

GH and ACTH co-secretion by two pituitary microadenomas

Ondruskova Dominika , Vanuga Peter , Pavaiova Anna

Introduction: Pituitary ACTH-dependent Cushing´s disease and acromegaly are rare conditions. Pituitary adenomas co-secreting GH and ACTH are even more unusual.Case report: A 29-year-old patient, mother of three children, long-term follow-up by an endocrinologist for a thyroid struma without an autoimmune basis, was sent in April 2023 for further examination for detection of hypercortisolemia and insufficient suppressibility in the overnight 1 mg dex...

ea0081ep184 | Calcium and Bone | ECE2022

The short test with active metabolites of vitamin D in differential diagnosis between primary normocalcemic and secondary hyperparathyroidism for inpatient treatment

Karaseva Elena , Eremkina Anna , Elfimova Alina , Gorbacheva Anna , Bibik Ekaterina , Kovaleva Elena , Mokrysheva Natalia

Objective: Normocalcemic primary hyperparathyroidism (PHPT) is a phenotype of PHPT characterized by normal serum calcium and persistently increased parathyroid hormone (PTH) after exclusion of secondary causes of PTH elevation.The aim: of this study was to investigate the capability of the short test with active metabolites of vitamin D for differential diagnosis between normocalcemic PHPT and secondary hyperparathyroidism (SHPT) for inpatient treatment....

ea0081ep573 | Endocrine-Related Cancer | ECE2022

Postoperative prediction of tumor recurrence in patients with nonfunctional pancreatic neuroendocrine tumors

Olearska Helena , Sowa-Staszczak Anna , Opalinska Marta , Kurzyńska Anna , Hubalewska-Dydejczyk Alicja

Introduction: Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group with various treatment options depending on grading, staging, and presence of symptoms related to hormonal secretion. Their incidence significantly increased over the past decade and nowadays constitutes 30% of all NETs of the gastrointestinal tract. Despite the evidence of a different malignancy potential of PNETs G2, postoperative management is the same in all patients. Ai...

ea0090p157 | Pituitary and Neuroendocrinology | ECE2023

Various cut-off points for paradoxical increase of growth hormone after glucose load in patients with acromegaly and their clinical implications

Godlewska Magdalena , Bogusławska Anna , Grochowska Anna , Hubalewska-Dydejczyk Alicja , Gilis-Januszewska Aleksandra

Introduction: Paradoxical increase of growth hormone after glucose load (PR) and its clinical significance remain the focus of researchers. Different cut off points for diagnosis of PR are used in the literature. Aim : Our aim was to investigate 3 different definitions of PR and their clinical implications.Material and Methods: We analyzed 116 consecutive patients diagnosed with acromegaly in 2012-2022. We included 89 patients with...

ea0090p168 | Pituitary and Neuroendocrinology | ECE2023

Quantitative assessment of the signal intensity of somatotropin pituitary tumors and its clinical implications in consecutive newly-diagnosed patients with acromegaly

Godlewska Magdalena , Bogusławska Anna , Grochowska Anna , Hubalewska-Dydejczyk Alicja , Gilis-Januszewska Aleksandra

Introduction: Somatotroph Pituitary Neuroendocrine Tumor’s (sPitNET) signal intensity in T2-weighted MR images (SI) was reported as prognostic marker for tumor’s aggressiveness and poor response to 1st generation somatostatin analogs (SSA). Tumors are arbitrary divided into 3 groups: hyperintensive (HYPER), isointensive (ISO) and hypointensive (HYPO). Aim: Our aim was to quantitatively assess SI of sPitNETs and investigate its clinic...

ea0090ep127 | Calcium and Bone | ECE2023

Key factors associated with impaired glucose metabolism in primary hyperparathyroidism

Bibik Ekaterina , Elfimova Alina , Gorbacheva Anna , Dobreva Ekaterina , Karaseva Elena , Gins Nikolay , Eremkina Anna , Mokrysheva Natalia

Background: Primary hyperparathyroidism (PHPT) can present with not only classic complications like bone and kidney pathology but also with different metabolic disorders and cardiovascular diseases. The prevalence of diabetes mellitus type 2 (DM2) in patients with PHPT is higher than in general population but the mechanism of carbohydrate metabolism alteration in PHPT remains unclear.Aim: The aim of this study is to estimate parameters associated with im...

ea0090ep133 | Calcium and Bone | ECE2023

The Russian Registry of primary hyperparathyroidism, the latest update

Eremkina Anna , Elfimova Alina , Miliutina Anastasiia , Kovaleva Elena , Gorbacheva Anna , Bibik Ekaterina , Mokrysheva Natalia

Introduction: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders. No major epidemiological research has been previously conducted in the Russia. This served as the basis for the creation of the Russian online registry of PHPT with accessibility from various regions of the country.Aim: Aim of this study was to estimate the clinical profile, surgical and medical therapy of the patients with different forms of PHPT.<p class...

ea0090ep138 | Calcium and Bone | ECE2023

Clinical characteristics of sporadic and MEN1-associated primary hyperparathyroidism in young patients

Aboishava Lizaveta , Elfimova Alina , Gorbacheva Anna , Salimkhanov Rustam , Eremkina Anna , Karaseva Elena , Mokrysheva Natalia

Introduction: Primary hyperparathyroidism (PHPT) is commonly the most early manifestation of multiple endocrine neoplasia syndrome type 1 (MEN1), but it can also occur in young patients without any inherited disorders. The aim of our study was to compare the clinical characteristics of PHPT in young patients with MEN1 syndrome and with sporadic disease.Patients and Methods: The study included 72 patients with MEN-1 associated PHPT and 168 patients with s...

ea0090ep149 | Calcium and Bone | ECE2023

The daily calcium profile in patients with chronic hypoparathyroidism depending on different 25(OH) vitamin D level

Kovaleva Elena , Eremkina Anna , Elfimova Alina , Karaseva Elena , Gorbacheva Anna , Aboishava Lizaveta , Mokrysheva Natalia

Introduction: Chronic hypoparathyroidism is a rare disease, which usually treated with active forms of vitamin D and oral calcium. Supplementation with native vitamin D can be useful both for achieving "non-skeletal" effects of vitamin D and for a more stable serum calcium profile.Aim: The aim of this study was to estimate the daily serum calcium and 24-hour urine calcium levels in patients with chronic hypoparathyroidism depending on different 2...

ea0090ep172 | Calcium and Bone | ECE2023

Epidemiological characteristics of cardiovascular diseases in primary hyperparathyroidism according to the Russian Registry

Dobreva Ekaterina , Eremkina Anna , Gorbacheva Anna , Bibik Ekaterina , Kovaleva Elena , Gins Nikolay , Mokrysheva Natalia

Objective: Primary hyperparathyroidism (PHPT) is associated with a higher incidence of different cardiovascular diseases (CVD), but the prevalence of CVD in PHPT remains unclear.Aim: To evaluate the prevalence of CVD in PHPT according to the RussianPHPT Registry.Materials and Methods: The Registry includes a database of patients with PHPT available at the Endocrinology Research Centre (Moscow) since 2007, which was transferred to t...